Ethnopharmacology, Phytochemistry, and Biological Properties of Medicinally Important Plants of Bignoniaceae Family: A Comprehensive Review

Malik  Saadullah; Maryam  Farrukh  <a target="_blank" href="https://orcid.org/0000-0001-5439-0284"><img src="https://lquestpub.com/assets/img/oric-id.png" width="17" alt="Oric Icon"></a> <a href="mailto:maryamfarrukh@gcuf.edu.pk"><i class="icofont icofont-email"></i></a>; Hamza  Sohail; Aiman  Atiq

doi:https://doi.org/10.66590/ijcmr2025020201

International Journal of Clinical and Medical Research

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ISSN Online: 3134-8831

About: International Journal of Clinical and Medical Research (IJCAMR) is an open-access, peer-reviewed journal dedicated to the publication of high-quality research in the field of clinical and medical sciences. The journal aims to provide a platform for researchers, clinicians, and healthcare professionals to share knowledge, exchange ideas, and promote scientific advancement in healthcare.

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International Journal of Clinical and Medical Research | Year 2025 | Volume 2 | Issue 2 | Pages 1-22

Ethnopharmacology, Phytochemistry, and Biological Properties of Medicinally Important Plants of Bignoniaceae Family: A Comprehensive Review

Malik Saadullah¹, Maryam Farrukh ^2*

, Hamza Sohail³ and Aiman Atiq⁴
^1,2,3,4Department of Pharmaceutical Chemistry, Faculty of Pharmaceutical Sciences, Govt. College University, Faisalabad-38000 Pakistan

View PDF Download XML Download DOI XML DOI: 10.66590/ijcmr2025020201

Abstract

Aim of the study: The family Bignoniaceae is also known as the "trumpet vine family". Majority of members of this family scattered throughout tropical America. Traditionally, plants of this family were used to treat various disorders, like neuralgia and varicose veins, diabetes, syphilis, ulcers, abscesses, rheumatism, gonorrhoea, and wounds. The biological characteristics, phytochemistry, and chemotaxonomic classification of the phytochemicals of several species of the family Bignoniaceae are highlighted in this paper. Materials and methods: The relevant information on the family Bignoniaceae was obtained from scientific databases (Google Scholar, ACS Publications, Wiley Online Library, Science Direct, PubMed). Information was also gathered from books and online databases. The literature cited in this review dates from 1971 to June 2022. Result: About 133 compounds have been isolated from various species of the family Bignoniaceae, including anthraquinones, sterols, terpenoids, benzoquinone, naphthoquinones, phthalide derivative, furanonaphthoquinones, phenolic acid and their derivatives, fatty acids, flavonoids, carotenoids, glycoside, dihydroisocoumarins, lignans, alkaloids, and sugars. Structures of these components are shown in tabular form. In biological studies, the crude extracts of the various species of the family Bignoniaceae show many biological properties, like antibacterial, antiviral, antifungal, antidiarrheal, anticancer, antioxidant, anticonvulsant, antidiabetic, antiplasmodial, analgesic, anti-inflammatory, antimalarial, anti-trypanosomal, antispasmodic, wound healing activity, cardioprotective, and larvicidal activity. The biological properties are also shown in tabular form.

How to cite this article

DOI: https://doi.org/10.66590/ijcmr2025020201

URL: https://lquestpub.com/article/10.66590/ijcmr2025020201

INTRODUCTION

According to a WHO report, the majority of traditional therapies use plant extracts and their active ingredients because they are safe and effective [1]. Over 80% of people worldwide rely on natural resources (especially plants) to treat their illnesses, either because of drug-resistant conditions or the negative side effects of modern medications [2]. Some justifications for using medicinal plants include their affordability, accessibility, and the perception that they are safer than manufactured medications [3]. The majority of herbal products are complex and vary in character, whether they are made from a single or a combination of botanical substances [4].

The existence of numerous secondary metabolites in medicinal plants, such as alkaloids, flavonoids, phenols, saponins, and sterols, may contribute to their therapeutic effects [5]. Many years ago, traditional medicinal herbs were used to treat a variety of diseases [6]. The herbs have anti-depressant, anti-asthmatic, post-coital antifertility activity, spermicidal activity, anti-parasitic activity, hepatoprotective, hypoglycaemic activity, anti-inflammatory, bronchoprotective, antiallergic, and nephroprotective properties [7].

A family of trees, shrubs, lianas, and sporadically herbaceous species is known as the Bignoniaceae [4]. It is a large family that is also known as the "trumpet vine family that is also known as the "trumpet vine family" or "trumpet creeper family" [8]. With more than 100 genera and around 800 species, the Bignoniaceae family is largely tropical. Figure 1 is showing few plants of Bignoniaceae Family [9]. Majority of its members scattered throughout tropical America [10].

The Bignoniaceae family includes important ornamental plants with gigantic, striking flowers [4]. The family is distinguished by the wide variety of vibrant, beautiful flowers they produce [8]. Alkaloids, flavones, polyphenols, naphthoquinones, tannins, triterpenes, seed oils, and iridoid glucosides are the main chemical constituents that are recognised in this family [11]. It consists of species which have been utilised traditionally for a variety of conditions [12] like fungus infections [13], snakebites, skin conditions, gynaecological conditions, cancer, cholera, gastrointestinal problems, respiratory issues, urinary problems, hepatic conditions, epilepsy, sexually transmitted diseases, pain, malaria, and heart conditions [14].

Figure 1: The plants of Bignoniaceae Family (a), Newbouldia laevis (P.Beauv.) Seem. (b), Campsis grandiflora K.Schum. (c), Zeyheria montana Mart. (d), Kigelia africana (Lam.) Benth. (e), Pyrostegia venusta Miers (f) Tabebuia impetiginosa Standl

Traditional Uses

An antinociceptive and anti-inflammatory action has been seen in extracts of the pods, leaves, or seeds of Catalpa bignonioides Walter [15]. The plant Jacaranda mimosifolia D. Don is used to treat hepatitis. The bark, flowers, and leaves of Jacaranda mimosifolia are used in conventional medicine to treat neuralgia and varicose veins [16]. Tabebuia impetiginosa Standl. contains antinociceptive, antibiotic, anti-edematogenic, and antidepressant properties [17]. Diabetes can be treated with the Tecoma stans (L.) Griseb. plant [18]. Backaches, syphilis, ulcers, abscesses, rheumatism, and wounds are all treated with Kigelia pinnata. (Jacq.) DC. [19]. The flowers of Spathodea campanulata Buch.-Ham. ex DC. are used to treat ulcers in Laos, Cambodia, and Vietnam. [16]. The leaves and bark of Markhamia stipulata Seem. ex K.Schum. are used both internally for analgesic effects and externally to treat skin disorders in conventional Thai treatment [20]. Leaves of Fernandoa adenophylla (Wall. ex G.Don) Steenis are used as an external therapy for skin conditions in traditional Thai medicine [21]. White skin patches (leukoderma, vitiligo) can be treated with the help of flowers and leaves of Fernandoa adenophylla [22]. Brazilian folk medicine uses Jacaranda cuspidifolia Mart. for pectoral and vulnerable treatments, as well as for the treatment of syphilis, gonorrhoea, and skin ulcers [23].

Phyto-Constituents

Phytochemicals, which have been demonstrated to help prevent, treat, or relieve a variety of health issues, are abundant in plants and herbs [24]. Several investigations on various plant species have been conducted recently in an effort to find chemicals that could be useful for various medical uses [25].

Compounds 1–133 were isolated from medicinally important genra of Bignoniaceae (Table 1). Commonly, Naphthoquinones are the major constituents of this family. Many terpenoids, anthraquinones, benzoquinone, naphthoquinones, phthalide derivative, furan naphthoquinones, fatty acid, sterols, phenolic compounds, flavonoids, carotenoids, glycoside, sugars, chalcone, ferulic esters and dihydroisocoumarins are reported in this family (Figure 2).

Terpenoids, including compounds 1–18 were isolated from Xantolis boniana var. boniana (twig and leaf extract), A. pulchra Sims (aerial part extract), A. triplinervia (leaf extract), N. laevis (root extract), C. grandiflora (flower extaract), Z. Montana (leaf extract), A. samydoides (leaf and stem extract), J. Decurrens (leaf extract), Macfadyena unguis-cati (liana extract), K. africana (leaf and fruit extract) and H. adenophyllum (leaf extract). Sterols and their derivatives: isolated from R. boniana (twig and leaf extract), R. xylocarpa (root extract), A. samydoides (leaf and stem extract), K. pinnatu (roots and bark extract) and Macfadyena unguis-cati (liana extract) are numbered 19-23 in Table 1.

Figure 2: A Schematic Diagram of Biological Activities of Different Plants of Bignoniaceae

Anthraquinones: isolated from S. zenkeri (stem-bark extract) and T. impetiginosa (bark extract) are numbered 24-27 in Table 1
Benzoquinone: only one compound, numbered 28 was isolated from N. laevis (root extract)
Naphthoquinones: isolated from K. pinnatu (root and fruit extract), N. laevis (root and stem-bark extract), T. undulate (stem-bark extract), T. avellanedue (stem-bark and whole plant extract), H. adenophyllum (stem and heartwood extract) and C. ovate (stem-bark extract) are numbered 29-53 in Table 1.
Phthalide derivative: only one compound, numbered 54 was isolated from C.ovate (stem-bark extract).
Furanonaphthoquinones: isolated from N. laevis (stem-bark extract), T. ochracea (stem-bark extract) and T.impetiginosa (bark extarct) are numbered 55-61 in Table 1.
Phenolic compounds: isolated from A. patellifera (aerial part extract), Macfadyena unguis-cati (liana extract), N. laevis (stem-bark extarct), K. pinnatu (roots and fruit extract), S. zenkeri (stem-bark extract), K. africana (stem-bark extract), T. aurea (Stem-bark extract) and A. pulchra (aerial part extract) are numbered 62-69 in Table 1
Fatty acids: isolated from Macfadyena unguis-cati (aerial part and seed extract) and Pyrostegia venusta (flower extract) are numbered 70-90 in Table 1
Flavonoids: isolated from A. samydoides (leaves and stem extract), A. brachypoda (leaf and root extract), Z. tuberculosa (stem extract), A. pulchra (aerial part extarcat), M. hortensis (leaf and flower extract), O.indicum (stem-bark extract), N. laevis (root and stem-bark extract), Macfadyena unguis-cati (liana extract), A. chica (leaf extract) and T. stans (fruit extract) are numbered 91-108 in Table 1
Carotenoids: isolated from A. chica (leaf extract) are numbered 109 and 110 in Table 1
Glycoside: isolated from S. cylindricum (leaf and branch extract), M. stipulate (leaf and branch extract), F. adenophylla (leaf and branch extract), J. cuspidifolia (bark extarct), N. laevis (stem-bar extarct), Barnettia kerrii (Leaf and branch extract) and A. pulchra (leaf exatrct) are numbered 111-123 in Table 1.
Dihydroisocoumarins: isolated from K. pinnatu (root and bark extract) are numbered 124-126 in Table 1
Lignans: only one compound, numbered 127 was isolated from Kigelia Africana (leaf and fruit extract)
Sugars: only one compound, numbered 128 was isolated from Tecoma stans (fruit extract)
Alkaloids: isolated from Tecoma stans (leaf and fruit extract) are numbered 129-132 in Table 1

Table 1: Phytochemical Compounds of Family Bignoniaceae

Structure No	Compound Name	Source Type	Part used	Reference.	Structures
Terpenoids
Triterpenoid
1	Bonianic acid A	Radermachera boniana	Twig and leaf extract	[70]
2	Bonianic acid B	Radermachera boniana	Twig and leaf extract	[70]
3	3-O-acetyluncaric acid	Radermachera boniana	Twig and leaf extract	[70]
4	Oleanolic acid	Radermachera boniana, Arrabidaea pulchra, Arrabidaea triplinervia, Newbouldia laevis, Campsis grandiflora	Twig and leaf extract Aerial part extract Leaf extract Root extract Flower extract	[36,70,71,72]
5	3-epioleanolic acid	Radermachera boniana	Twig and leaf extract	[70]
6	Arjunolic acid	Campsis grandiflora	Flower extract	[72]
7	Corosolic acid	Campsis grandiflora	Flower extract	[72]
8	Maslinic acid	Campsis grandiflora	Flower extract	[72]
9	Ursolic acid	Radermachera boniana, Zeyheria Montana, Arrabidaea samydoides, Arrabidaea triplinervia, Jacaranda Decurrens, Campsis grandiflora	Twig and leaf extract Leaf extract Leaf and stem extract Leaf extract Leaf extract Flower extract	[70,71,73,74]

10	Lupeol	Arrabidaea samydoides, Macfadyena unguis-cati Kigelia Africana	Leaf and stem extract Liana extract Leaf extract	[71,75,76]
11	Uvaol	Arrabidaea samydoides	Leaf and stem extract	[71]
12	Erythrodiol	Arrabidaea samydoides	Leaf and stem extract	[71]
13	Pomolic acid	Arrabidaea triplinervia, Kigelia africana	Leaf extract Leaf extract	[71,76]
14	β-amyrin	Haplophragma adenophyllum	Leaf extract	[77]
15	Fibrarecisin	Kigelia africana	Leaf extract	[76]
16	Betulin	Pyrostegia venusta	Flower extract	[78]
17	Betulinic acid	Pyrostegia venusta	Flower extract	[78]
18	Canophyllol	Kigelia africana	Leaf and fruit extract	[76]

Sterols and their derivatives
19	Ergosterol peroxide	Radermachera boniana	Twigs and leaf extract	[70]
20	Stigmasterol	Radermachera xylocarpa, Arrabidaea samydoides Kigelia pinnatu	Root extract Leaf and stem extract Roots and bark extract	[71,79,80]
21	Sitosterol	Arrabidaea samydoides	Leaf and stem extract	[71]
22	β-sitosterol	Macfadyena unguis-cati Kigelia pinnatu	Liana extract Roots and bark extract	[75,80]
23	β-sitostenone	Radermachera boniana	Twigs and leaf extract	[70]
Anthraquinones
24	Zenkequinones A	Stereospermum zenkeri	Stem-bark extract	[40]
25	Zenkequinones B	Stereospermum zenkeri	Stem-bark extract	[40]
26	2-(hydroxymethyl) anthraquinone	Tabebuia impetiginosa	Bark extract	[26]
27	Anthraquinone-2-carboxylic acid	Tabebuia impetiginosa	Bark extract	[26]
Benzoquinone
28	2,3-dimethoxy-1,4-benzoquinone	Newbouldia laevis	Root extract	[36]
Naphthoquinones
29	Kigelinone	Kigelia pinnata	Root and fruit extract	[81]

30	Isopinnatal	Kigelia pinnata	Root and fruit extract	[81]
31	Dehydro-α-lapachone	Kigelia pinnata	Root and fruit extract	[81]
32	Lapachol	Kigelia pinnata, Newbouldia laevis, Tecomella undulate, Tubebuiu avellanedue, Heterophragma adenophyllum	Root and fruit extract Root extract Stem-bark extract Stem-bark extract Stem-heartwood extract	[36,81,82,83,84]
33	8-methoxydehydroiso-α-lapachone	Catalpa ovate	Stem-bark extract	[85]
34	9-methoxy-4-oxo-α-lapachone	Catalpa ovate	Stem-bark extract	[86]
35	(4S,4aR,10R,10aR)-4,10-dihydroxy-2,2-dimethyl-2,3,4,4 α,10,10 α hexahydrobenzo[g]chromen-5-one	Catalpa ovate	Stem-bark extract	[86]
36	3-hydroxydehydroiso-α-lapachone	Catalpa ovate Heterophragma adenophyllum	Stem-bark extract Heartwood extract	[85,87]
37	4,9-dihydroxy-α-lapachone	Catalpa ovate	Stem-bark extract	[85]
38	4-hydroxy-α-lapachone	Catalpa ovate	Stem-bark extract	[85]
39	9-methoxy-α-lapachone	Catalpa ovate	Stem-bark extract	[85]

40	4-oxo-α-lapachone	Catalpa ovate		[86]
41	5-hydroxy-dehydro-iso-α-lapachone	Newbouldia laevis	Stem-bark extract	[88]
42	3,8-dihydroxydehydroiso-α-lapachone	Heterophragma adenophyllum	Heartwood extract	[87]
43	α-lapachone	Catalpa ovate	Stem extract	[86]
44	Catalponone	Catalpa ovate	Stem extract	[86]
45	Catalponol	Catalpa ovate	Stem extract	[86]
46	β-Lapachone	Tabebuia avellanedae	Whole plant extract	[86]
47	Dilapachone	Haplophragma adenophyllum	Heartwood extract	[77]
48	Adenophyllone	Haplophragma adenophyllum	Heartwood extract	[77]
49	2-acetyl-4H,9H-naphtho[2,3-b]furan4,9-dione	Tabebuia serratifolia	Bark extract	[26]

50	2-(1-hydroxyethyl)-4H,9H-naphtho[2,3-b] furano-4,9-dione	Tabebuia serratifolia	Bark extract	[26]
51	4-Hydroxy-2-(3-hydroxy-2-methoxy-3-methyl-butylidene)- 3,4-dihydro-2H-naphthalen-1-one	Catalpa ovate	Stem extract	[86]
52	α-xiloidone	Tabebuia avellanedae	Wood extract	[29]
53	Epicatalponol	Catalpa bignonioides	Heartwood extract	[89]
Phthalide derivative
54	Catalpalactone	Catalpa ovate	Stem-bark extract	[85]
Furanonaphthoquinones
55	5-hydroxy-dehydroiso-α-lapachone	Newbouldia laevis	Stem-bark extract	[88]
56	2-isopropenylnaphtho[2,3-b]furan-4,9-dione	Newbouldia laevis	Stem-bark extract	[88]
57	2-(1'-methylethenyl)- 5-hydroxynaphtho[2,3-b]furan-4,9-dione	Newbouldia laevis	Stem-bark extract	[88]
58	2-(1'-methylethenyl)-7-hydroxy-naphtho[2,3-b]furan-4,9-dione	Newbouldia laevis	Stem-bark extract	[88]
59	5,8-Dihydroxy-2-(1′-hydroxyethyl)naphtho[2,3-b]- furan-4,9-dione	Tabebuia ochracea	Stem-bark extract	[90]

60	8-Hydroxy-7-methoxy-2-acetylnaphtho[2,3-b]furan-4,9-dione	Tabebuia ochracea	stem bark extract	[90]
61	5-Hydroxy-2-( 1 -hydroxyethyl)naphtho[2,3-b] furan-4,9-dione	Tabebuia impetiginosa	Bark extract	[91]
Phenolic compounds
62	p-Coumaric acid	Kigelia pinnata, Arrabidaea pulchra, Stereospermum zenkeri	Root and fruit extract Aerial part extract Stem-bark extract	[40,71,81]
63	Ferulic acid	Kigelia pinnata	Root and fruit extract	[81]
64	Chlorogenic acid	Macfadyena unguis-cati	Liana extract	[75]
65	Caffeic acid	Kigelia pinnata	Root and fruit extract	[81]
66	Atraric acid	Newbouldia laevis	Stem-bark extract	[88]
67	Atranorin	Kigelia africana	Stem-bark extract	[92]
68	Veratric acid	Tabebuia aurea	Stem-bark extract	[38]
69	Mangiferin	Arrabidaea patellifera	Aerial part extract	[71]
Fatty acids
Saturated
70	Dodecanoic acid (Lauric acid)	Macfadyena unguis-cati	Aerial part extract	[93]
71	Tetradecanoic acid (Myristic acid)	Macfadyena unguis-cati	Aerial part extract	[93]
72	Pentadecenoic acid (Pentadecylic acid)	Macfadyena unguis-cati	Aerial part extract	[93]
73	Arachidonic acid (Eicosanoic acid)	Macfadyena unguis-cati	Aerial part extract	[93]
74	Heneicosylic acid (Heneicosanoic acid)	Macfadyena unguis-cati	Aerial part extract	[93]

75	Behenic acid (Docosanoic acid)	Macfadyena unguis-cati	Aerial part extract	[93]
76	Tricosylic acid (Tricosanoic acid)	Macfadyena unguis-cati	Aerial part extract	[93]
77	Lignoceric acid (Tetracosanoic acid)	Macfadyena unguis-cati	Aerial part extract	[93]
78	Pentacosylic acid (Pentacosanoic acid)	Macfadyena unguis-cati	Aerial part extract	[93]
79	Cerotic acid (Hexacosanoic acid)	Macfadyena unguis-cati	Aerial part extract	[93]
80	Montanic acid (Octacosanoic acid)	Macfadyena unguis-cati	Aerial part extract	[93]
81	Melissic acid (Triacontanoic acid)	Macfadyena unguis-cati	Aerial part extract	[93]
82	Pentadecanoic acid, 14- methyl	Macfadyena unguis-cati	Aerial part extract	[93]
83	Heptadecanoic acid, 14 methyl	Macfadyena unguis-cati	Aerial part extract	[93]
84	Hexadecanoic acid,14-methyl	Macfadyena unguis-cati	Aerial part extract	[93]
85	Heptadecanoic acid,16-methyl	Macfadyena unguis-cati	Aerial part extract	[93]
Monounsaturated
86	Palmitoleic acid	Macfadyena unguis-cati	Seed extract	[93]
87	Cis-vaccenic acid	Macfadyena unguis-cati	Seed extract	[93]
88	11-hexadecenoic acid	Macfadyena unguis-cati	Aerial part extract	[93]
89	Oleic acid	Pyrostegia venusta	Flower extract	[78]
Polyunsaturated
90	Linoleic acid	Pyrostegia venusta	Flower extract	[78]
Flavonoids
Flavone
91	Chrysin	Arrabidaea samydoides, Oroxylum indicum	Leaf and stem extract Stem-bark extract	[71,94]
92	Cirsiliol	Arrabidaea brachypoda	Leaf extract	[71]
93	5,6,7,8-Tetramethoxyflavone	Zeyheria tuberculosa	Stem extract	[41]
94	5,6,7-Trimethoxyflavone	Zeyheria tuberculosa	Stem extract	[41]
95	4’-Hydroxy-5,6,7,8-tetramethoxyflavone	Zeyheria tuberculosa	Stem extract	[41]

96	4’-Hydroxy-5,6,7-trimethoxyflavone	Zeyheria tuberculosa	Stem extract	[41]
97	Hispidulin	Arrabidaea brachypoda, Millingtonia hortensis	Leaf extract Leaf and flower extract	[71,95]
98	Hortensin	Millingtonia hortensis	Flower extract	[95]
99	Apigenin	Arrabidaea brachypoda, Newbouldia laevis	Leaf extract Stem-bark extract	[71,76]
100	Luteolin	Arrabidaea brachypoda, Newbouldia laevis	Leaf and root extract Stem bark extract	[71,76]
101	Scutellarein	Arrabidaea chica Oroxylum indicum	Leaf extract Stem-bark extract	[71,94]
102	Chrysoeriol	Newbouldia laevis	Root extract	[36]
103	6-hydroxyluteolin-7-O-ß-glucoside	Arrabidaea pulchra	Aerial part extract	[71]
104	Baicalein	Oroxylum indicum	Stem-bark extract	[94]
105	6-Methoxyluteolin (Nepetin)	Oroxylum indicum	Stem-bark extract	[94]
Flavonol
106	Rutin	Arrabidaea brachypoda Tecoma stans	Leaf extract Fruit extract	[71,97]

107	Kaempferol	Arrabidaea chica	Leaf extract	[71]
108	Quercitrin	Macfadyena unguis-cati	Liana extract	[75]
Carotenoids
109	α-carotene	Arrabidaea chica	Leaf extract	[71]
110	β-carotene	Arrabidaea chica	Leaf extract	[71]
Glycoside
Iridoid glucosides
111	Stereospermoside	Stereospermum cylindricum	Leaf and branch extract	[98]
112	Ajugol	Stereospermum cylindricum	Leaf and branch extract	[98]
113	Specioside	Stereospermum cylindricum	Leaf and branch extract	[98]
114	Verminoside	Stereospermum cylindricum	Leaf and branch extract	[98]
phenylethanoid glycosides
115	Verbascoside	Arrabidaea pulchra, Jacaranda cuspidifolia, Newbouldia laevis	Leaf extract Bark extract Stem-bark extract	[23,71,88]

116	Isoverbascoside	Stereospermum cylindricum	Leaf and branch extract	[98]
117	Markhamiosides A	Markhamia stipulate	Leaf and branch extract	[20]
118	Salidroside	Fernandoa adenophylla	Leaf and branch extract	[21]
119	Leucosceptoside A	Fernandoa adenophylla	Leaf and branch extract	[21]
120	Martynoside	Fernandoa adenophylla	Leaf and branch extract	[21]
Phenolic glycoside
121	Khaephuoside A	Barnettia kerrii	Leaf and branch extract	[99]

122	khaephuoside B	Markhamia stipulate	Leaf and branch extract	[20]
123	Seguinoside K	Barnettia kerrii	Leaf and branch extract	[99]
Dihydroisocoumarins
124	Kigelin	Kigelia pinnatu	Root extract	[80]
125	6-demethylkigelin	Kigelia pinnatu	Root extract	[80]
126	6-methoxymellein	Kigelia pinnate	Root and bark extract	[80]
Lignan
127	Sesamin	Kigelia Africana	Leaf and fruit extract	[76]
Sugars
128	Sucrose	Tecoma stans	Fruit extract	[97]
Alkaloids
129	5b-Hydroxyskitanthine	Tecoma stans	Leaf extract	[100]
130	7-hydroxydehydroskytanthine	Tecoma stans	Fruit extract	[100]
131	4-hydroxytecomanine	Tecoma stans	Fruit extract	[100]
132	Tecomanine	Tecoma stans	Fruit extract	[100]

Biological Properties

The Bignoniaceae family has medicinal value because it contains secondary metabolites like fatty acids, glycosides, terpenoids, phenolic compounds naphthoquinones, alkaloids, flavonoids, and carotenoids. The biological activities of numerous species of the Bignoniaceae family are shown below in Table 2.

Table 2: Biological Activity of Species of Family Bignoniaceae

Biological activity	Plant sources	Inferences	Reference.
Antibacterial activity	Tabebuia ochracea	At doses between 1.25 and 10 mg/well, an ethyl acetate extract of inner bark of T. ochracea prevents the formation of Staphylococcus aureus.	[26,69]
	Kigelia pinnata	The methanol extract of K. pinnata has the highest antibacterial activity against Proteus vulgaris and Salmonella typhi, intermediate antibacterial activity against S. aureus, E. coli, and B. cereus, but lower antibacterial activity against Klebsiella pneumonia, P. aeruginosa and Enterobacter aerogens.	[27]
	Tabebuia rosea	It has also been determined that the ethanol extract derived from leaves of T. rosea can stop Klebsiella pneumonia from growing at doses between 50,000 and 30,000 mg/L (50 and 300 mg/mL).	[28]
	Jacaranda oxyphylla	Ethanol extracts from J. oxyphyll leaves were discovered to have a relevant effect against Gram-positive bacteria (S. aureus and B. cereus).	[37]
	Tabebuia avellanedae	T. avellanedae's hexane extract shown antibacterial effects against and methicillin-sensitive Staphylococcus aureus and methicillin-resistant Staphylococcus aureus.	[29]
	Tecoma stans	Leaf extract of Tecoma stans exhibit a potential broad spectrum antibacterial activity.	[30]
	Pyrostegia venusta	Pyrostegia venusta extract had antibacterial efficacy against Salmonella typhimurium , Staphylococcus aureus, Klebsiella pneumoniae, Pseudomonas aeruginosa, Bacillus cereus, Shigella sonnei and Escherichia coli.	[22]
	Tabebuia impetiginosa	Campylobacter jejuni was unaffected by T. impetiginosa hydro-alcoholic extract, which only had a 36% inhibitory effect on Helicobacter pylori growth.	[32]
	Tabebuia chrysantha	Dose of 125,000 mg/L (125 mg/mL) of methanolic extract of T. chrysantha leaf stopped the growth of Staphylococcus aureus.	[33]
	Jacaranda mimosaefolia	E. coli, S. typhi, B. cereus, and S. aureus are among the gram negative and gram positive bacteria that methanolic leaf extract from Jacaranda mimosaefolia is effective against.	[34]
	Jacaranda acutifolia	Xanthomonas campestris growth was suppressed by jacaranda acutifolia extract.	[35]
	Jacaranda cuspidifolia	J. cuspidifolia's methanolic extract shown antibacterial action against S. aureus, S. Pyogenes and N. gonorrheae.	[23]
	Newbouldia laevis	When compared to the standard antibiotics gentamycin and nystatin, Newbouldiaquinone A compound of Newbouldia laevis was 24 and 13 times more effective against Enterobacter aerogens and Candida gabrata, respectively.	[36]
Antimicrobial activity	Tabebuia aurea	The chemicals identified in T. aurea demonstrated a broad spectrum of efficacy against Gram negative and Gram positive bacteria and also against alcohol-acid bacteria and fungus in microbiological experiments	[38]
	Kigelia pinnata	Kigelia pinnata's crude aqueous extract shown strong antimicrobial activity.	[39]
	Stereospermum zenkeri	The best antibacterial activity against gram-negative Pseudomonas aeruginosa was demonstrated by the compound zenkequinone B of Stereospermum zenkeri (MIC 9.50 μg/mL).	[40]
	Zeyheria tuberculosa	Extracts and isolated flavones from Z. tuberculosa may be very effective against the pathogenic bacteria S. aureus and C. albicans.	[41]

Antifungal activity	Tabebuia avellanedae	Dichloromethane extract from bark of T. avellanedae has a significant antifungal effect, particularly against Microsporum gypseum, Aspergillus fumigatus, Saccharomyces cerevisiae, Candida albicans, and Trichophyton mentagrophytes.	[42]
	Tabebuia caraiba	Dose of 20,000 mg/L (20 mg/mL) of an ethanol extract from T. caraiba suppressed the growth of Candida albicans.	[43]
	Tabebuia avellanedae	Candida parapsilosis, Candida albicans, Candida krusei, Candida dubliniensis, Candida rugosa, Candida lusitaniae, and Candida glabrata are all inhibited by methanol extract from T. avellanedae, with MIC values ranging from 60 to 0.1 mg/L (0.06 to 0.0001 mg/mL).	[44]
	Tecoma stans	Extracts demonstrated antifungal efficacy against Candida albicans, Cryptococcus neoformans, and Microsporum gypsum.	[45]
Antiviral activity	Tabebuia impetiginosa	The extract of Tabebuia impetiginosa exhibited anti-HHV-1 action, with an EC₅₀ of 166.6 µg/mL.	[46]
Antidiarrhoeal activity	Kigelia pinnata	When compared to atropine, the antidiarrheal impact of Kigelia pinnata at 500 mg/kg was found to be 82% and 62.7% on small intestine motility and castor oil-induced diarrhoea, respectively.	[47]
Anticancer activity	Kigelia pinnata	Methanolic extract of Kigelia pinnata significantly killed off human tumour cell lines.	[48]
	Tabebuia avellanedae	When taken orally, Tabebuia avellanedae's aqueous extract reduced the nociception caused by acetic acid.	[50]
	Tecoma stans	The leaf extract from Tecoma stans shown a considerable antiproliferative action. At concentrations of 7.8 g/mL and 1000 g/mL, extracts demonstrated minimum inhibition of 14.6% and maximal inhibition of 95.9%, respectively.	[49]

	Kigelia pinnata	Due to the existence of a high phenolic content, the ethyl acetate fraction of root of Kigelia pinnata exhibits excellent antioxidant activity against DPPH. It has strong antioxidant properties that prevent peroxidation of lipid, lower level of glutathione, and increase CAT and SOD activity.	Atolani et al.
	Pyrostegia venusta	The fraction of ethyl acetate from Pyrostegia venusta roots demonstrates good antioxidant property against DPPH because it has a high phenolic content.	[31]
	Tecoma stans	Dose of 20 µg/mL of methanolic extract from T. stans demonstrated significant antioxidant activity.	[51]
	Tabebuia impetiginosa	The methanolic extract and syrup of Tabebuia impetiginosa had strongest antioxidant activity.	[17]
Antidiabetic activity	Parmentiera edulis	After being given to rats with alloxan-induced diabetes, the substance lactucin-8-O-methylacrylate of Parmentiera edulis reduces sugar levels in blood.	[33]
	Tecoma stans	Tecoma stans stimulates glucose absorption in both insulin-resistant and insulin-sensitive human and murine adipocytes, contributing to its anti-diabetic properties.	[52]
	Kigelia pinnata	The amylase inhibition assay was used to evaluate the anti-diabetic effect from leaf extract of Kigelia pinnata and results showed that it has strong efficacy against diabetes.	[53]
Anti-convulsant activity	Spathodea campanulata	Following oral administration, an ethanol extract of S. campanulata has anticonvulsant properties against PTZ, picrotoxin and MES-induced seizures in mice.	[101]
Anti-convulsant activity	Kigelia pinnata	PTZ (pentylene tetrazole) and MES (maximal 45 electro shock) induced convulsions were significantly prevented by methanolic extract of Kigelia pinnata.	[54]
Anti-plasmodial activity	Spathodea campanulata	Aqueous extract of leaf and the most polar portion of the chloroform extract of Spathodea campanulata showed a high amount of activity against Plasmodium herghei berghei in mice.	[55]
Anti-inflammatory activity	Tabebuia avellanedae	The expression of iNOS and COX-II, arachidonic acid-induced ear edoema and the production of NO and PGE2 were all inhibited by Tabebuia avellanedae water extract through preventing the phosphorylation of ERK.	[59]
	Jacaranda decurrens	Without inducing acute toxicity, jacaranda decurrens extract exhibits anti-inflammatory effects in rats.	[58]
	Pyrostegia venusta	30-300 mg/kg oral administration of hydroethanolic extract of Pyrostegia venusta showed an anti-inflammatory effect. Paw edoema was reduced and leukocyte migration into the peritoneal cavity was prevented by hydroethanolic extract of Pyrostegia venusta.	[56]
	Kigelia pinnata	The ethanolic extract of Kigelia pinnata's stem bark has been shown to have strong anti-inflammatory effects.	[57]
	Tabebuia impetiginosa	The generation of NO and PGE2, as well as the mRNA levels of COX-2 and iNOS was reduced by a water extract of Tabebuia impetiginosa.	[17]
Analgesic activity	Stereospermum kunthianum	The findings suggest that the analgesic activity from stem-bark of kunthianum in its aqueous extract is mediated by peripheral and central processes.	[61]
Analgesic activity	Kigelia pinnata	K. pinnata leaf extract significantly reduced the pain caused by thermal noxious stimuli.	[60]
Larvicidal activity	Millingtonia hortensis	When tested on the three mosquito species Anopheles Stephensi, Aedes Aegypti, and Culex quinquefasciatus, acetone extract of the leaves of illingtonia hortensis was effective against all larval stages of these species.	[62]
Antinociceptive activity	Pyrostegia venusta	In Swiss male mice exposed to acetic acid-induced writhing, extracts of Pyrostegia venusta demonstrated antinociceptive action.	[56]
Cardioprotective effect	Tecoma stans	In a dose-dependent way, treatment with a 70% ethanolic extract of T. stans flowers has blocked the decline of GSH, SOD, and CAT levels.	[63]
Wound healing activity	Pyrostegia venusta	Pyrostegia venusta extract has a strong capacity for wound healing. Pyrostegia venusta extract was discovered to up-regulate TNF- α and IL-6 levels during the early stages of wound healing.	[22]
Wound healing activity	Tecoma stans	In excision and incision wound models, Tecoma stans bark methanolic extract exhibits greater wound healing properties than chloroform and petroleum ether extracts.	[64]
Antispasmodic effect	Tecoma stans	Without involving β-adrenoceptors, opioid receptors, potassium channels, or NO generation, Tecoma stans leaf extract produces its antispasmodic actions.	[65]
Antimalarial activity	Newbouldia laevis	In vitro parasitic development of Plasmodium falciparum is moderately chemo-suppressed by the antimalarial compound Newbouldiaquinone A of Newbouldia laevis.	[66]
Antimalarial activity	Kigelia pinnata	The antimalarial efficacy of wood extract of Kigelia pinnata is superior to chloroquine and quinine against drug-resistant strains of Plasmodium falciparum.	[67]
Anti-trypanosomal activity	Tabebuia pulcherrima	After only 48 hours, leaf extract from T. pulcherrima revealed IC₅₀ values of 7.8 g/mL.	[68]
	Tabebuia pallida	After only 48 hours, leaf extract from T. pallida revealed IC₅₀values of 7.2 g/mL.	[68]
	Tabebuia rosea	After 48 and 72 hours, an extract of the stem of T. rosea exhibited activity with IC₅₀ of 13.4 and 16.2 g/mL, respectively.	[68]
	Tabebuia serratifolia	The chloroform extract of bark of T. serratifolia was reported to be effective against Trypa-nosoma cruzi with an inhibition percent greater than 96%.	[69]

Antibacterial Activity

At doses between 1.25 and 10 mg/well, an ethyl acetate extract of inner bark of T. ochracea prevents the formation of Staphylococcus aureus [26]. The methanol extract of K. pinnata has the highest antibacterial activity against Proteus vulgaris and Salmonella typhi, intermediate antibacterial activity against S. aureus, E. coli, and B. cereus, but lower antibacterial activity against Klebsiella pneumonia, P. aeruginosa and Enterobacter aerogens [27]. It has also been determined that the ethanol extract derived from leaves of T. rosea can stop Klebsiella pneumonia from growing at doses between 50,000 and 30,000 mg/L (50 and 300 mg/mL) [28]. T. avellanedae's hexane extract shown antibacterial effects against and methicillin-sensitive Staphylococcus aureus and methicillin-resistant Staphylococcus aureus [29]. Leaf extract of T. stans exhibit a potential broad spectrum antibacterial activity [30]. Pyrostegia venusta extract had antibacterial efficacy against Salmonella typhimurium , Staphylococcus aureus, Klebsiella pneumoniae, Pseudomonas aeruginosa, Bacillus cereus, Shigella sonnei and Escherichia coli [31]. Campylobacter jejuni was unaffected by T. impetiginosa hydro-alcoholic extract, which only had a 36% inhibitory effect on Helicobacter pylori growth [32]. Dose of 125,000 mg/L (125 mg/mL) of methanolic extract of T. chrysantha leaf stopped the growth of Staphylococcus aureus [33]. J. cuspidifolia's methanolic extract shown antibacterial action against S. aureus, S. Pyogenes and N. gonorrheae [23]. E. coli, S. typhi, B. cereus, and S. aureus are among the gram negative and gram positive bacteria that methanolic leaf extract from Jacaranda mimosaefolia is effective against [34]. Xanthomonas campestris growth was suppressed by j. acutifolia extract [35]. When compared to the standard antibiotics gentamycin and nystatin, Newbouldiaquinone A compound of Newbouldia laevis was 24 and 13 times more effective against Enterobacter aerogens and Candida gabrata, respectively [36]. Ethanol extracts from J. oxyphyll leaves were discovered to have a relevant effect against Gram-positive bacteria (S. aureus and B. cereus) [37].

Antimicrobial Activity

The chemicals identified in T. aurea demonstrated a broad spectrum of efficacy against Gram negative and Gram positive bacteria and also against alcohol-acid bacteria and fungus in microbiological experiments [38]. Kigelia pinnata's crude aqueous extract shown strong antimicrobial activity [39]. The best antibacterial activity against gram-negative Pseudomonas aeruginosa was demonstrated by the compound zenkequinone B of Stereospermum zenkeri (MIC 9.50 μg/mL) [40]. Extracts and isolated flavones from Z. tuberculosa may be very effective against the pathogenic bacteria S. aureus and C. albicans [41].

Antifungal Activity

Dichloromethane extract from bark of T. avellanedae has a significant antifungal effect, particularly against Microsporum gypseum, Aspergillus fumigatus, Saccharomyces cerevisiae, Candida albicans, and Trichophyton mentagrophytes [42]. Dose of 20,000 mg/L (20 mg/mL) of an ethanol extract from T. caraiba suppressed the growth of Candida albicans [43]. Candida parapsilosis, Candida albicans, Candida krusei, Candida dubliniensis, Candida rugosa, Candida lusitaniae, and Candida glabrata are all inhibited by methanol extract from T. avellanedae, with MIC values ranging from 60 to 0.1 mg/L (0.06 to 0.0001 mg/mL) [44]. Extracts of Tecoma stans demonstrated antifungal efficacy against Candida albicans, Cryptococcus neoformans, and Microsporum gypsum [45].

Antiviral Aactivity

The extract from T. impetiginosa shown anti-HHV-1 action, with an EC₅₀value of 166.6 µg/mL [46].

Antidiarrhoeal

When compared to atropine, the antidiarrheal impact of Kigelia pinnata at 500 mg/kg was found to be 82% and 62.7% on small intestine motility and castor oil-induced diarrhoea, respectively [47].

Anticancer

Methanolic extract of Kigelia pinnata significantly killed off human tumour cell lines [48]. The leaf extract from Tecoma stans shown a considerable antiproliferative action. At concentrations of 7.8 g/mL and 1000 g/mL, extracts demonstrated minimum inhibition of 14.6% and maximal inhibition of 95.9%, respectively [49]. When taken orally, Tabebuia avellanedae's aqueous extract reduced the nociception caused by acetic acid [50].

Antioxidant Activity

Due to the existence of a high phenolic content, the ethyl acetate fraction of root of Kigelia pinnata exhibits excellent antioxidant activity against DPPH. It has strong antioxidant properties that prevent peroxidation of lipid, lower level of glutathione, and increase CAT and SOD activity. The fraction of ethyl acetate from Pyrostegia venusta roots demonstrates good antioxidant property against DPPH because it has a high phenolic content [31]. The methanolic extract and syrup of Tabebuia impetiginosa had strongest antioxidant activity [17]. Dose of 20 µg/mL of methanolic extract from T. stans demonstrated significant antioxidant activity [51].

Anti-Diabetic Activity

Tecoma stans stimulates glucose absorption in both insulin-resistant and insulin-sensitive human and murine adipocytes, contributing to its anti-diabetic properties [52]. The amylase inhibition assay was used to evaluate the anti-diabetic effect from leaf extract of Kigelia pinnata and results showed that it has strong efficacy against diabetes [53]. After being given to rats with alloxan-induced diabetes, the substance lactucin-8-O-methylacrylate of Parmentiera edulis reduces sugar levels in blood [33].

Anti-Convulsant Activity

After oral administration, an ethanol extract from S. campanulata has anticonvulsant properties against pentylene tetrazole (PTZ), picrotoxin and maximal 45 electro shock (MES) induced seizures in mice. PTZ and MES induced convulsions were significantly prevented by methanolic extract of Kigelia pinnata [54].

Antiplasmodial Activity

Aqueous extract of leaf and the most polar portion of the chloroform extract of Spathodea campanulata showed a high amount of activity against Plasmodium herghei berghei in mice [55].

Anti-Inflammatory

30-300 mg/kg oral administration of hydroethanolic extract of Pyrostegia venusta showed an anti-inflammatory effect. Paw edoema was reduced and leukocyte migration into the peritoneal cavity was prevented by hydroethanolic extract of Pyrostegia venusta [56]. The ethanolic extract of Kigelia pinnata's stem bark has been shown to have strong anti-inflammatory effects [57]. The generation of NO and PGE2, as well as the mRNA level of iNOS and COX-2 was reduced by a water extract of Tabebuia impetiginosa [17]. Without inducing acute toxicity, Jacaranda decurrens extract exhibits anti-inflammatory effects in rats [58]. The expression of iNOS and COX-II, arachidonic acid-induced ear edoema and the production of NO and PGE2 were all inhibited by Tabebuia avellanedae water extract through preventing the phosphorylation of ERK [59].

Analgesic Activity

K. pinnata leaf extract significantly reduced the pain caused by thermal noxious stimuli [60]. The findings suggest that the analgesic activity from stem-bark of Stereospermum kunthianum in its aqueous extract is mediated by peripheral and central processes [61].

Larvicidal Activity

When tested on the three mosquito species Anopheles Stephensi, Aedes Aegypti, and Culex quinquefasciatus, acetone extract of the leaves of illingtonia hortensis was effective against all larval stages of these species [62].

Antinociceptive Activity

In Swiss male mice exposed to acetic acid-induced writhing, extracts of Pyrostegia venusta demonstrated antinociceptive action [56].

Cardioprotective Effect

In a dose-dependent way, treatment with a 70% ethanolic extract of T. stans flowers has blocked the decline of GSH, SOD, and CAT levels [63].

Wound Healing Activity

Pyrostegia venusta extract has a strong capacity for wound healing. Extract was discovered to up-regulate TNF- α and IL-6 levels during the early stages of wound healing [22]. In excision and incision wound models, Tecoma stans bark methanolic extract exhibits greater wound healing properties than chloroform and petroleum ether extracts [64].

Antispasmodic Effect

Without involving β-adrenoceptors, opioid receptors, potassium channels, or NO generation, Tecoma stans leaf extract produces its antispasmodic actions [65].

Antimalarial

In vitro parasitic development of Plasmodium falciparum is moderately chemo-suppressed by the antimalarial compound Newbouldiaquinone A of Newbouldia laevis [66]. The antimalarial efficacy of wood extract of Kigelia pinnata is superior to chloroquine and quinine against drug-resistant strains of Plasmodium falciparum [67].

Anti-Trypanosomal Activity

After only 48 hours, leaf extract from T. pulcherrima revealed IC₅₀ values of 7.8 g/mL. After only 48 hours, leaf extract from T. pallida revealed IC₅₀ of 7.2 g/mL. After 48 and 72 hours, an extract of the stem of T. rosea exhibited activity with IC₅₀ of 13.4 and 16.2 g/mL, respectively [68]. Chloroform extract of bark of T. serratifolia was reported to be effective against Trypanosoma cruzi with an inhibition percent greater than 96% [69].

Future perspective

Based on available data on medicinal plant of the Bignoniaceae family, these plants are used in treatment of disease like hepatitis, neuralgia, diabetes, backaches, syphilis, ulcers, abscesses, white skin patches, rheumatism, syphilis, gonorrhoea, and ulcers. This family can therefore have regarded as a significant family in folk medicinal practices. It is because of the presence of phytochemical constituents that have many effective biological activities, and this could potentially aid researchers in the discovery of novel natural drugs. Therefore, plants of Bignoniaceae family can become significant sources of novel drugs and lead compound. A clinical trial must be conducted to better understand their safety and efficacy. Other species that have not yet been investigated should be the subject of more research.

CONCLUSION

This review focuses on phytochemical components of various species of family Bignoniaceae and also highlights the importance of these species. The plants of this family possess high amounts of secondary metabolites such as anthraquinones, sterols, terpenoids, benzoquinone, flavonoids, naphthoquinones, furanonaphthoquinones, carotenoids, glycoside, and sugars. Overall 132 compounds of this family are highlighted in this review. Due to the presence of these compounds, species belonging to the family Bignoniaceae are considered to be an important resource for treating various ailments like antibacterial, antiviral, antifungal, antidiarrheal, anticancer, antioxidant, anticonvulsant, antidiabetic, analgesic, antimalarial, anti-trypanosomal, and cardioprotective.

Conflict of Interest

All authors declare no competing interests.

Credit Authorship Statement

M.Sajid Hamid Akash, participated in literature analysis and manuscript editing. Malik Saadullah, contributed to the conception of the study. Maryam Farrukh designed the main structure of the manuscript. Aiman Atiq and Hamza Sohail done the manuscript editing. All authors reviewed and approved the final version of manuscript.

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Key Words

BignoniaceaeBiological PropertiesTraditional UsesPhytochemistry

Article History

Received September 23, 2025
Accepted November 15, 2025
Published December 30, 2025

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Copyright: © 2025 This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source is properly cited.