Aim of the study: The family Bignoniaceae is also known as the "trumpet vine family". Majority of members of this family scattered throughout tropical America. Traditionally, plants of this family were used to treat various disorders, like neuralgia and varicose veins, diabetes, syphilis, ulcers, abscesses, rheumatism, gonorrhoea, and wounds. The biological characteristics, phytochemistry, and chemotaxonomic classification of the phytochemicals of several species of the family Bignoniaceae are highlighted in this paper. Materials and methods: The relevant information on the family Bignoniaceae was obtained from scientific databases (Google Scholar, ACS Publications, Wiley Online Library, Science Direct, PubMed). Information was also gathered from books and online databases. The literature cited in this review dates from 1971 to June 2022.  Result: About 133 compounds have been isolated from various species of the family Bignoniaceae, including anthraquinones, sterols, terpenoids, benzoquinone, naphthoquinones, phthalide derivative, furanonaphthoquinones, phenolic acid and their derivatives, fatty acids, flavonoids, carotenoids, glycoside, dihydroisocoumarins, lignans, alkaloids, and sugars. Structures of these components are shown in tabular form. In biological studies, the crude extracts of the various species of the family Bignoniaceae show many biological properties, like antibacterial, antiviral, antifungal, antidiarrheal, anticancer, antioxidant, anticonvulsant, antidiabetic, antiplasmodial, analgesic, anti-inflammatory, antimalarial, anti-trypanosomal, antispasmodic, wound healing activity, cardioprotective, and larvicidal activity. The biological properties are also shown in tabular form.