Nurse burnout and excessive workload in terminally ill patients’ wards represent critical barriers to effective Inter-Professional Collaboration (IPC) in Pakistani tertiary hospitals. This research article synthesizes findings from a quantitative survey of 105 nurses in Civil and Allied Hospitals, Faisalabad (Hamna Zulifqar thesis), with recent empirical studies on palliative care in Pakistan. The majority of nurses reported “nice operating relationships” with doctors yet identified excessive workload, staff shortages, additional ward-management duties and patient-attendant interference as primary stressors leading to job strain, insomnia, hypertension and family-life disruption. These factors erode timely communication, shared decision-making and emotional support within physician-nurse teams, directly compromising palliative care outcomes such as symptom management, family satisfaction and dignified end-of-life care. Literature from Aga Khan University Hospital (Karachi) and other tertiary settings corroborates high burnout rates (60–86% emotional exhaustion in oncology/palliative units) linked to understaffing (1 nurse per 3000+ patients vs. WHO standards) and cultural stigma around nursing. Using descriptive statistics and chi-square analysis from the primary dataset, this study demonstrates statistically significant associations between workload, burnout indicators and perceived collaboration quality. Proposed low-cost interventions structured joint ward rounds, shared debriefing sessions and targeted resilience training offer actionable pathways for medical students and residents to test during clinical rotations. Addressing these pressures is essential for sustainable IPC and improved palliative outcomes in resource-constrained Pakistani healthcare systems.