107-LQP-JABS 20260903105623 Lumina Quest Publishing m.arslansohail@gmail.com Lumina Quest Publishing Journal of Advanced Biological Sciences J. Adv. Biol. Sci. 3134-8823 10.66590/jabs https://lquestpub.com/archives.php?journal=journal-of-advanced-biological-sciences 06 30 2026 06 30 2026 3 1 10.66590/jabs20260301 https://lquestpub.com/articles-list.php?journal=journal-of-advanced-biological-sciences&volume=3&issue=1 Modifiable Behavioral and Psychosocial Determinants of Primary Female Infertility: A Mechanistic Narrative Review Hamdan Siddig Sirag Ahmad Einas Mustafa Mudawi Ahmed Rania Abdeen H Abdalla Abeer Hassan Elhaj Rana Aboras R. Ahmed sahoud Al-Sultany Mohammed Abdelrazig Ahmed Elrofaie Fatima Diab Mohammed Osman Mwahib Mohamed Ahmed Naglaa Ahmed Abdellatif Ginawi Primary female infertility is a complex, multifactorial reproductive disorder influenced by unmodifiable organic etiologies as well as modifiable behavioral and psychosocial factors. This narrative review synthesizes current molecular, cellular and endocrine evidence linking body composition, physical activity, dietary patterns and psychological distress to primary female reproductive dysfunction. We highlight specific physiological pathways, including hypothalamic Gonadotropin-Releasing Hormone (GnRH) pulsatility, the hypothalamic-pituitary-adrenal (HPA) axis, follicular microenvironment oxidative stress and peripheral insulin signaling. Furthermore, actionable clinical guidelines for preconception lifestyle modifications are provided alongside prioritized future research avenues. Routine evaluation of modifiable lifestyle parameters represents an essential component of comprehensive reproductive healthcare. 06 30 2026 06 30 2026 25 27 10.66590/jabs2026030105 https://lquestpub.com/article/10.66590/jabs2026030105