63-LQP-JABS 20260903105656 Lumina Quest Publishing m.arslansohail@gmail.com Lumina Quest Publishing Journal of Advanced Biological Sciences J. Adv. Biol. Sci. 3134-8823 10.66590/jabs https://lquestpub.com/archives.php?journal=journal-of-advanced-biological-sciences 12 30 2025 12 30 2025 2 2 10.66590/jabs20250202 https://lquestpub.com/articles-list.php?journal=journal-of-advanced-biological-sciences&volume=2&issue=2 Multi-Omics Approaches in Diagnostic Pathology: An Updated Review of Current Evidence Aarav Mehta Nisha Verma Mohammed Faisal Diagnostic pathology has undergone a remarkable transformation from a predominantly morphology-based discipline to an integrated field that combines histopathology, immunohistochemistry, molecular pathology, and computational biology. The emergence of multi-omics approaches—including genomics, transcriptomics, proteomics, metabolomics, epigenomics, and spatial omics—has enabled comprehensive characterization of disease biology by providing complementary molecular insights. These technologies have significantly advanced precision medicine by improving disease classification, facilitating early and accurate diagnosis, identifying clinically actionable biomarkers, predicting therapeutic response, and uncovering mechanisms of treatment resistance. Furthermore, the integration of multi-omics data through advanced computational and artificial intelligence–driven analytical methods has enhanced diagnostic accuracy and personalized clinical decision-making. This review provides a comprehensive overview of current multi-omics technologies, their applications in diagnostic pathology, computational integration strategies, clinical significance, existing challenges, and future directions for their implementation in precision diagnostics and personalized medicine. 12 30 2025 12 30 2025 20 21 10.66590/jabs2025020204 https://lquestpub.com/article/10.66590/jabs2025020204