53-LQP-JABS 20240630000000 Lumina Quest Publishing m.arslansohail@gmail.com Lumina Quest Publishing Journal of Advanced Biological Sciences J. Adv. Biol. Sci. 3134-8823 10.66590/jabs https://lquestpub.com/archives.php?journal=journal-of-advanced-biological-sciences 06 30 2024 06 30 2024 1 1 10.66590/jabs20240101 https://lquestpub.com/articles-list.php?journal=journal-of-advanced-biological-sciences&volume=1&issue=1 Hematological Impact of Ethanolic Extract of Cocos Nucifera in Apparently Healthy Albino Rats B.A. Erinle A.O. Ajayi. O.E. Bada Background: Cocos nucifera is widely utilized as a medicinal plant due to its accessibility and diverse therapeutic applications. This study aimed to evaluate the hematological effects of its ethanolic extract in apparently healthy albino rats. Methods: Fifty albino rats were randomly assigned into five groups (A–E), with ten animals per group. Groups B, C, D and E received oral doses of 100, 200, 400 and 800 mg/kg body weight of ethanolic extract of Cocos nucifera daily for 14 days, while Group A served as the untreated control. Animals were monitored for physical and behavioral changes throughout the experimental period. At the end of the study, blood samples were collected into Ethylenediaminetetraacetic Acid (EDTA) tubes for hematological analysis and lithium heparin tubes for biochemical assays. Evaluated hematological parameters included Hemoglobin (Hb), Packed Cell Volume (PCV), White Blood Cell Count (WBC), Red Blood Cell Count (RBC), differential Leukocyte Count and Red Cell Indices (MCV, MCH, MCHC). Serum biochemical analyses were performed using commercially available Randox kits. Results: Administration of the ethanolic extract of Cocos nucifera husk resulted in a non-significant increase (p>0.05) in the evaluated hematological parameters across treated groups compared to controls. These findings suggest that the extract did not produce any adverse alterations in the hematological profile of the animals. Conclusion: The ethanolic extract of Cocos nucifera was well tolerated in apparently healthy albino rats and did not significantly affect hematological parameters, indicating its relative safety following oral administration. 06 30 2024 06 30 2024 34 36 10.66590/jabs2024010105 https://lquestpub.com/article/10.66590/jabs2024010105